Back in early December we reported that the Proto-Goblin might be appearing in the 2012 Spider-Man reboot played by actor Irrfan Khan.
However, Irrfan Khan, refutes that, as he tells the Indian news webiste, Global Desi (bold my own):
While he is looking forward to Spiderman, the 48-year-old confesses, that initially he wasn’t keen on the project. “I didn’t want to be part of this violent American fantasy. But both my sons were excited and kept insisting that I take it up.” But the intricacy and freshness of the script finally won. Even then, Irrfan placed one condition before Webber — he didn’t want to be a masked villain or become another creature. Spiderman’s schedule in Los Angeles will follow his March shoot for Life of Pi in Taiwan.
You can see what the Proto-Goblin looks like. So looks like Khan may just be playing a normal role.